Which patient population should NOT receive Propofol?

Propofol is a sedative-hypnotic agent commonly used for anesthesia and sedation. It is generally contraindicated in patients with head injuries due to its potential effects on intracranial pressure and cerebral perfusion. Propofol can lead to a decrease in systemic vascular resistance and may cause hypotension, which can further compromise the already vulnerable states of patients with head injuries. Maintaining adequate cerebral perfusion pressure is critical in this population, and the use of Propofol could exacerbate any elevations in intracranial pressure or lead to inadequate cerebral blood flow, posing a significant risk.

In contrast, while there are considerations for using Propofol in other populations such as the elderly, pediatric patients, and those with kidney disease, these groups may still receive Propofol with appropriate monitoring and dose adjustments based on clinical judgment. Each of these populations has unique considerations, but none are absolute contraindications like in the case of head injury patients.