What is a common sign of exposure to chemical nerve agents in canines?

Salivation is a well-documented sign of exposure to chemical nerve agents in canines. Nerve agents, such as organophosphates, disrupt normal neurotransmission by inhibiting the enzyme acetylcholinesterase. This inhibition leads to an accumulation of acetylcholine in the synapses, resulting in overstimulation of the parasympathetic nervous system. One of the classic manifestations of this overstimulation is increased salivation, often referred to as "sialorrhea."

In canines, this excessive production of saliva occurs alongside other clinical signs of nerve agent exposure, such as muscle twitching, difficulty breathing, and vomiting, which are influenced by the autonomic responses of the body. Salivation serves as an important indicator for first responders in a tactical or hazardous materials scenario, helping to identify potential exposure to these dangerous substances.